منابع مشابه
Microexons Go Big
Microexons are frequently underestimated in transcriptome analyses. Two studies published in Cell and Genome Research now independently report the identification of hundreds of microexons. Alternative splicing of some microexons is regulated by neuronal-specific RNA-binding proteins and modifies the function of proteins involved in neurogenesis, with misregulation linked to autism.
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D eradication is an attractive public health goal. In addition to eliminating illnesses and deaths, eradication can lead to substantial cost savings. Eradication has been attempted for many human and animal diseases, such as smallpox, malaria, hookworm disease, polio, rinderpest, yaws, dracunculiasis (guinea worm disease), and yellow fever, and many tools have been employed in these efforts. Bu...
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In this issue Yvonne Martin provides us with a ‘‘Perspective’’ addressing an important and too often overlooked problem in chemistry, biology, and drug discovery, tautomerism. As she notes, the extent of this issue goes beyond common expectations. The phenomenon shines a bright light on the limitations of our methods of chemical structure representation and data basing. The problem is multifold...
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Big Data analytics and Cloud Computing are headlining the current IT initiatives. The information pool that is generated worldwide doubles every 20 month. Echoing McKinsey [17], Big Data refers to dataset sizes that are beyond the ability of typical database tools to capture, store, manage, and analyze the data assets. There is no explicit definition of how big a dataset has to be to be labeled...
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The big bang-big crunch (BB-BC) algorithm is a popular metaheuristic optimization technique proposed based on one of the theories for the evolution of the universe. The algorithm utilizes a two-phase search mechanism: big-bang phase and big-crunch phase. In the big-bang phase the concept of energy dissipation is considered to produce disorder and randomness in the candidate population while in ...
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ژورنال
عنوان ژورنال: Communications of the ACM
سال: 2018
ISSN: 0001-0782,1557-7317
DOI: 10.1145/3192027